APPLICATIONS

Applications

3D-all-organelle real time visualization of a single cell

Real time fly-through of a toponome map composed of appr 7,000 multi-protein clusters inside a single human primary liver cell: from inside the nuclear structures (nucleoli, and DNA) over the nuclear envelope and the perinuclear endoplasmic reticulum, toward the cis-Golgi vesicles and the ectatic Golgi cisterna with intracisternal compacted proteins. (after: Schubert w et al. Nat Biotechnol 24, 1270-1278, 2006)
Visualizing the protein-DNA network code inside the cell nucleus

Real time 100-parameter slicing across thousands of protein clusters in a single human tissue section

100-molecular parameter real time slicing across thousands of distinct multi-protein clusters in a single skin tissue section for direct comparison and clear-cut distinction of protein networks in the involved psoriatic and non-involved skin.
Real time 100-parameter protein profiling in a single human tissues section
100-molecular parameter real time protein profiling of thousands of distinct multi-protein clusters in a single skin tissue section for direct comparison of protein networks in the psoriatic skin and uninvolved morphologically normal skin.
Imaging Cycler® TIS™ on human FFPE (formalin fixed paraffin embedded) lymphoid tissue I:
Cyclical image acquisition and proteincluster mapping (CMP toponome maps)
Imaging Cycler® TIS™ on human FFPE (formalin fixed paraffin embedded) lymphoid tissue II
Real time protein profiling
Imaging Cycler® TIS™ on human FFPE (formalin fixed paraffin embedded) lymphoid tissue III
Real time slicing across receptor complexes.
3D Graph-based real time visualization of subcellular protein networks

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